Estimating the proportion of neutral mutants
نویسندگان
چکیده
منابع مشابه
The Proportion of Mutants in Bacterial Cultures
The proportion of mutants in a growing culture of organisms will depend upon (a) the rate at which the wild cells produce them (with or without growth), (b) the back mutation rate, and (c) the growth rates of the wild and mutant cells. If the mutation rate without growth and the back mutation rate are neglected, the growth of a mutant is expressed by See PDF for Equation and the ratio of the mu...
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The number of terramycin-resistant mutants in Bacillus megatherium cultures, their mutation rate, and the growth rate of the wild and mutant cells have been determined under various conditions. These values are in agreement with the following equations (Northrop and Kunitz, 1957):- See PDF for Equation lambda = mutation rate, A = growth rate constant of wild cells, B = growth rate constant of m...
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Mutation testing is often used to assess the quality of a test suite by analyzing its ability to distinguish between a base program and its mutants. The main threat to the validity/ reliability of this assessment approach is that many mutants may be syntactically distinct from the base, yet functionally equivalent to it. The problem of identifying equivalent mutants and excluding them from cons...
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Multiple testing procedures, such as the False Discovery Rate control, often rely on estimating the proportion of true null hypotheses. This proportion is directly related to the minimum of the density of the p-value distribution. We propose a new estimator for the minimum of a density that is based on constrained multinomial likelihood functions. The proposed method involves partitioning the s...
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ژورنال
عنوان ژورنال: Genetical Research
سال: 1987
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672300023569